Why should this litany be depicted on the walls of a church in Arta? Three women that stand out among the crowds may provide the answer. They are Anna Palaiologina, wife of Nikephoros I, ruler of the Despotate of Epirus, her sister Theodora Raoulaina, and her mother Irene-Eulogia, sister of the emperor Michael VIII Palaiologos. The three women were vocal opponents of the emperor’s efforts to restore the unity of the Greek Orthodox and Roman Catholic Church. They fell into disfavour with the emperor but their status was restored when Michael passed away. The fresco seems like a praise and an expression of gratitude towards Anna Palaiologina and her family for their leading role in this crucial ecclesiastical matter.